Table 2. Results of cosinor analysis of the clock gene expression profiles.
| PER1 | BMAL1 | |||
|---|---|---|---|---|
| Cosinor analysis | Controls | AD patients | Controls | AD patients |
| P | < 0.001 | < 0.001 | 0.0058 | 0.0015 |
| R2 | 0.2831 | 0.2213 | 0.1105 | 0.1490 |
| Acrophase (mean ± SEM) | 12.0 ± 0.6 | 11.6 ± 0.7 | 23.0 ± 1.1 | 2.1 ± 0.9 |
| Amplitude (mean ± SEM) | 25.1 ± 4.3 | 24.3 ± 5.1 | 14.8 ± 4.5 | 18.3 ± 4.9 |
| Mesor (mean ± SEM) | 44.1 ± 2.9 | 47.1 ± 3.4 | 47.8 ± 3.1 | 42.7 ± 3.3 |
P (statistical significance); R2 (coefficient of determination); Acrophase (the phase angle of the peak of a cosine curve in hours); Amplitude (the difference between the peak or trough and the mean value of a cosine curve); Mesor (the average value around which the variable oscillates)