Table 2.

Multivariate Analysis.^*

End Point	Hazard Ratio (95% CI)	P Value
Recurrence, second primary breast cancer, second primary nonbreast invasive cancer, or death without recurrence of cancer
Tumor grade		0.13
Intermediate vs. low	1.56 (0.92–2.63)
High vs. low	2.05 (0.92–4.55)
Tumor size >2 cm vs. ≤2 cm	1.17 (0.71–1.92)	0.54
Age		0.07
51–60 yr vs. ≤50 yr	0.87 (0.46–1.64)
61–75 yr vs. ≤50 yr	1.53 (0.87–2.70)
Lumpectomy vs. mastectomy	0.63 (0.38–1.06)	0.07
Recurrence at a distant site
Tumor grade of high or intermediate vs. low†	3.83 (0.48–30.69)	0.14
Tumor size >2 cm vs. ≤2 cm	1.55 (0.38–6.31)	0.55
Age		0.27
51–60 yr vs. ≤50 yr	1.28 (0.12–4.22)
61–75 yr vs. ≤50 yr	3.49 (0.42–29.16)
Lumpectomy vs. mastectomy	0.57 (0.12–2.82)	0.47
Recurrence at any site
Tumor grade		0.02
Intermediate vs. low	8.07 (1.06–61.45)
High vs. low	4.73 (0.29–76.42)
Tumor size >2 vs. ≤2 cm	1.06 (0.33–3.33)	0.93
Age		0.33
51–60 yr vs. ≤50 yr	0.41 (0.10–1.73)
61–75 yr vs. ≤50 yr	0.98 (0.32–3.02)
Lumpectomy vs. mastectomy	0.93 (0.32–2.71)	0.89

^*Data from 1578 of 1626 patients with a recurrence score of 0 to 10 were included in these analyses. Data from 48 patients for whom the histologic grade of the tumor was not reported were excluded from these analyses.

^†Data from patients with a high tumor grade and those with an intermediate tumor grade were combined for the analysis of freedom from the recurrence of breast cancer at a distant site because of the small number of events.