Table 3.
Event Rates at 5 Years, According to Histologic Grade.*
| Tumor Grade | Invasive Disease– free Survival (95% CI) |
Freedom from Distant Recurrence (95% CI) |
Freedom from Any Recurrence (95% CI) |
Overall Survival (95% CI) |
|---|---|---|---|---|
| All grades | 93.8 (92.4–94.9) | 99.3 (98.7–99.6) | 98.7 (97.9–99.2) | 98.0 (97.1–98.6) |
| Low grade | 95.8 (93.5–97.3) | 99.8 (98.3–100) | 99.8 (98.3–100) | 98.7 (97.0–99.4) |
| Intermediate grade | 93.6 (91.7–95.1) | 99.0 (98.0–99.5) | 98.2 (97.0–99.0) | 97.9 (96.8–98.7) |
| High grade | 91.3 (83.9–95.4) | 100 (NC–NC) | 98.7 (91.1–99.8) | 97.3 (91.9–99.1) |
The analyses for all tumor grades included data from all 1626 patients who had a recurrence score of 0 to 10, including the 48 patients with the tumor grade not reported. A total of 530 patients were included in the analyses for low-grade tumor, 937 in the analyses for intermediate-grade tumor, and 111 in the analyses for high-grade tumor. In the time-to-event analysis of invasive disease–free survival (primary end point), the rate indicates freedom from the first event of recurrence of ipsilateral breast tumor, local recurrence, regional recurrence, distant recurrence, contralateral second primary invasive cancer, second primary nonbreast invasive cancer (excluding nonmelanoma skin cancer), or death without evidence of recurrence (which corresponds to the standardized definitions for efficacy end points [STEEP]23 definition of invasive disease–free survival). In the time-to-event analysis of recurrence of breast cancer at a distant site, the rate indicates freedom from the first event of distant recurrence of breast cancer or death with distant recurrence, if death was the first manifestation of distant recurrence (which corresponds to the STEEP distant recurrence–free interval definition). In the time-to-event analysis of freedom from any recurrence, the rate indicates freedom from the first recurrence of breast cancer (ipsilateral breast cancer, local or regional recurrence, or distant recurrence) or the date of death with recurrence, if death was the first manifestation of recurrence (which corresponds to the STEEP recurrence-free interval definition). NC denotes not calculated.