Table 1. Deficiencies that are synthetic lethal with sub and/or dominantly enhance Incenpmyc.
| Deficiency | Cytology | Viabilitya | Totala | % X-nondisjunctionb | Totalb | Candidate genes |
|---|---|---|---|---|---|---|
| sub | 20.3 | 1438 | ||||
| + | 1.3 | 158 | ||||
| Df(3L)emc-E12 | 61A;61D3 | 30.1 | 272 | 22.6 | 257 | fwd |
| Df(3L)ED4177 | 61C1;61E2 | 67.0 | 309 | 2.6 | 1440 | fwd |
| Df(3L)GN24 | 63F6-63F7;64C8-64C9 | 0 | 118 | 1.2 | 1027 | pavarotti |
| Df(3L)Exel9000 | 64A10;64A12 | 30.1 | 359 | 5.3 | 219 | pavarotti |
| Df(3L)ZN47 | 64C4-64C6;65D2 | 0 | 98 | 2.1 | 391 | Mad2, RCC1 |
| Df(3L)rdgC-co2 | 77A1;77D1 | 7.3 | 191 | polo | ||
| Df(3L)ri-XT1 | 77E2-77E4;78A2-78A4 | 6.1 | 70 | 12.2 | 460 | Spc105R, pitsire |
| Df(3L)BSC452 | 77E1;77F1 | 39 | 163 | 13.1 | 565 | |
| Df(3L)BSC449 | 77F2;78C2 | 122 | 180 | 4.8 | 565 | |
| Df(3R)Antp17 | 84A1-84A5;84D9 | 16.7 | 28 | |||
| Df(3R)DG2 | 89E1-89F4;91B1-91B2 | 0 | 36 | 0.0 | 297 | Deterin |
| Df(3R)ED5780 | 89E11;90C1 | 8.7 | 577 | |||
| Df(3R)BSC43 | 92F7;93B6 | 10.1 | 89 | 0.0 | 439 | |
| Df(3R)23D1 | 94A3-94A4;94D1-94D4 | 0 | 175 | 6.1 | 457 | |
| Df(3R)Exel6191 | 94A6;94B2 | 113.3 | 224 | 3.8 | 311 | |
| Df(3R)Exel6273 | 94B2;94B11 | 112.3 | 155 | 4.5 | 532 | |
| Df(3R)ED6091 | 94B5;94C4 | 158.1 | 191 | 0.0 | 156 | |
| Df(3R)Exel6192 | 94B11;94D3 | 111.1 | 133 | 6.0 | 807 | ND |
| Df(3R)Exel9013 | 95B1;95B5 | 132.8 | 288 | 8.4 | 1197 | ND |
| Df(3R)Exel9014 | 95B1;95D1 | 0 | 49 | 11.1 | 2234 | ND |
| Df(3R)Exel6196 | 95C12;95D8 | 140.6 | 77 | 6.5 | 2043 | ND |
a
Percentage viability was calculated from the ratio of sub131/sub1;Df/+::sub131/sub1;+/+ flies obtained (Figure S2).
b
X-chromosome nondisjunction was measured by crossing females to y Hw w/BSY males (Materials and Methods).