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. 2016 Jan 5;11(1):e0146427. doi: 10.1371/journal.pone.0146427

Fig 1. The antinociceptive effects produced by the intraperitoneal administration of CoPP at 5 and 10 mg/kg in STZ injected mice.

Fig 1

The development of mechanical allodynia (A), thermal hyperalgesia (B) and thermal allodynia (C) in the hind paws of control and diabetic mice intraperitoneally treated with vehicle or CoPP at 5 and 10 mg/kg from day 21 to day 25 after STZ injection is shown. Data of tests are shown at day 0 (before diabetes induction) and at days 21 and 25 after STZ injection (one and five days after initiation of CoPP administration, respectively). Data are expressed as von Frey filaments strength (g) for mechanical allodynia, withdrawal latency (s) for thermal hyperalgesia and paw lifts (number) for thermal allodynia. For each day, * indicates significant differences vs. CTRL mice (p< 0.05, one-way ANOVA followed by the Student Newman Keuls test) and + indicates significant differences vs. STZ mice treated with CoPP at 10 mg/kg (p< 0.05, one-way ANOVA followed by the Student Newman Keuls test). The results are shown as the mean values ± SEM; n = 6–8 animals per group.