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. 2016 Jan 5;11(1):e0146427. doi: 10.1371/journal.pone.0146427

Fig 3. Effects of CoPP treatment on the antiallodynic and antihyperalgesic responses to morphine.

Fig 3

Mechanical antiallodynic (A), thermal antihyperalgesic (B), and thermal antiallodynic (C) effects of the subcutaneous administration of 0.5 mg/kg of morphine or saline in STZ-injected mice pretreated with vehicle (DMSO 1%) or 10 mg/kg of CoPP. The effects of the intraperitoneal administration of CoPP alone are also shown. Data are expressed as von Frey filaments strength (g) for mechanical allodynia, withdrawal latency (s) for thermal hyperalgesia and paw lifts (number) for thermal allodynia. For each behavioral test, * denotes significant differences versus control group treated with vehicle plus saline (p< 0.05, one-way ANOVA followed by Student Newman Keuls test), + denotes significant differences versus group treated with vehicle plus morphine (p< 0.05, one-way ANOVA followed by the Student Newman Keuls test) and # denotes significant differences versus group treated with CoPP plus saline (p< 0.05; one-way ANOVA followed by the Student Newman Keuls test).