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Agar plates containing the hla–lacZ (PC322), the rnaIII-lacZ (SH101F7) or spa–lacZ (PC203) reporter strains of S. aureus were exposed to DMSO (20 μL) containing the test compound (0.5 mg/mL). Vehicle (DMSO), H2O, AIP-I (autologous) and AIP-III (heterologous) were used as controls. Virulence gene down-regulation is represented by a white zone and up-regulation by a darker than background blue zone.
