Table 1. Characteristics of DNA mismatch repair gene mutation carriers included in the study.
| No colorectal cancer (n=706) N (%) | Colorectal cancer (n=392) N (%) | All (n=1098) N (%) | |
|---|---|---|---|
| Sex | |||
| Male | 273 (38.8) | 193 (49.2) | 466 (42.5) |
| Female | 433 (61.2) | 199 (50.8) | 631 (57.5) |
| Ascertainment | |||
| Population-based | 47 (6.7) | 41 (10.5) | 88 (8.0) |
| Clinic-based | 659 (93.3) | 351 (89.5) | 1010 (92.0) |
| Gene mutated | |||
| EPCAM | 13 (1.8) | 5 (1.3) | 18 (1.6) |
| MLH1 | 247 (35.0) | 173 (44.1) | 420 (38.3) |
| MSH2 | 317 (45.0) | 164 (41.8) | 481 (43.8) |
| MSH6 | 95 (13.4) | 32 (7.9) | 126 (11.5) |
| PMS2 | 34 (4.8) | 19 (4.9) | 53 (4.8) |
| Agea mean (SD) | 43.9 (13.6) | 42.2 (11.4) | 43.2 (12.8) |
| Median [range] | 42 [9 - 89] | 42 [16 - 86] | 42 [9 - 89] |
a
Age at diagnosis for carriers with colorectal cancer; age at diagnosis of other cancer or polypectomy or death or last contact for carriers without colorectal cancer.