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. 2015 Nov;6(11-12):472–479. doi: 10.18632/genesandcancer.87

Figure 1. Schematic representation of relative transcriptional activities of SREBFs in association with cholestrerogenic/lipogenic target genes.

Figure 1

SREBF genes comprise SREBF1 (that encodes the alternative transcripts SREBF1c and SREBF1a) and SREBF2. SREBF1c mainly controls the expression of lipogenic genes, SREBF1a can activate both lipogenic and cholesterogenic genes and SREBF2 activates mainly the cholesterogenic genes and lipogenic genes with lower affinity [This figure is a modification of a previously published figure [30]].