Table 1. Global CNV burden in NPC patients and healthy controls.

	Ratea		Gene count (GRate)b		Gene count (GRich)c
	Case/control ratio	P-valued	Case/control ratio	P-valued	Case/control ratio	P-valued
Types
Deletion	0.8421	0.9432	0.9967	0.5112	2.2589	0.0310*
Amplification	1.2225	0.0029**	0.9426	0.677	1.3646	0.2043
Size
<100kb
Deletion	0.8849	0.9945	1.2726	0.8394	2.8430	0.0085**
Amplification	1.3108	0.0022**	1.2394	0.0816	1.2736	0.1975
≥100kb
Deletion	0.7314	0.9874	0.8658	0.7288	1.0636	0.3843
Amplification	1.1217	0.1739	0.8587	0.8292	1.1051	0.2074
Frequency
Rare	0.9120	0.8867	0.9924	0.5443	1.5081	0.1318
Common	0.9967	0.5326	3.9612	4x10-05***	5.6200	0.0007***

^aRate: Number of CNVs per individual

^bGene count (GRate): Number of genes spanned by CNVs per individual

^cGene count (GRich): Number of genes per total CNV kb

^dP-value: Based on comparison between cases and controls, one-sided, permuted 100,000 times

*0.01<P-value<0.05

**10⁻⁰⁴<P-value<0.01

***P-value<10⁻⁰⁴