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. 2016 Jan 5;11(1):e0146259. doi: 10.1371/journal.pone.0146259

Fig 2. Anti-allodynic effect of PKR antagonist (PC1) administration.

Fig 2

Anti-allodynic effect of PC1 administration as a single bolus (A) or as repeated administrations (B, C). A: acute PC1(s.c. 150 μg/ kg) was administered 21 days after MLD-STZ. B: therapeutic PC1 protocol- PC1 was administered (s.c. 150 μg/ kg, twice-daily) for 14 days, from day 21 to 35 after MLD-STZ. C: preventive PC1 treatment-PC1 was administered (s.c. 150 μg /kg, twice-daily) for 14 days, starting from day 0, time point corresponding to the first STZ administration. Data represent mean± SEM of 6 mice / group. Two way ANOVA was used for statistical evaluation, followed by Bonferroni’s test. ***p<0.001 vs vehicle/CTR and CTR + PC1; °°p<0.01, °°°p<0.001 vs STZ.