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. 2016 Jan 5;11(1):e0146259. doi: 10.1371/journal.pone.0146259

Fig 7. Effects of therapeutic PC1 administrations on cytokine production by macrophage and splenocytes.

Fig 7

(A) Effect of therapeutic PC1 administrations (s.c. 150 μg/ kg, twice-daily for 14 days from day 21 to 35 after MLD-STZ) on IL-1β (a) and IL-10 (b) production by peritoneal macrophages. Data represent mean± SEM of 6–8 mice per group. (B) Effect of therapeutic PC1 administrations (s.c. 150 μg/ kg, twice-daily for 14 days from day 21 to 35 after MLD-STZ) on IFN-γ (a), IL-2 (b), IL-4 (c) and IL-10 (d) production by splenocytes. (C) Splenocyte Th1/Th2 profile was expressed as IFN-γ/IL-4 ratio and calculated by setting IFN-γ/IL-4 ratio of the control as 100%. Cytokine content, evaluated by ELISA, was reported as protein concentrations in culture media. Data represent mean ±SEM of 6 mice per group. One way ANOVA was used for statistical evaluation, followed by Tukey’s test for multiple comparisons. *p<0.05 vs vehicle/ CTR; °p<0.05 vs STZ.