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. 2016 Jan 5;11(1):e0146432. doi: 10.1371/journal.pone.0146432

Fig 3. Statin attenuates H. pylori CagA-induced pathogenesis.

Fig 3

(A) AGS cells were transfected with κB-Luc vector and incubated for 24 h. The cells were then treated with 25 μM simvastatin, and infected with H. pylori at an MOI of 100 for 6 h. The cells were then prepared for luciferase activity assays. (B) AGS cells were pretreated with simvastatin (25 μM) prior to infection with H. pylori at an MOI of 100 for 16 h. The concentration of IL-8 in the culture supernatant was analyzed using the ELISA method. Results are expressed as means ± standard deviations. *, P < 0.05 was considered statistically significant.