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. 2016 Jan 5;11(1):e0146337. doi: 10.1371/journal.pone.0146337

Fig 3. Ipragliflozin improved fibrosis.

Fig 3

(A) Liver sections from BD, AMLN and SGLT2I mice. Masson’s trichrome (MT), (B) Sirius red (SR) staining. Areas of SR staining in the liver of BD, AMLN, and SGLT2I mice (n = 5–8). (C) Expression of collagen 1α1 mRNA, and α-smooth muscle actin α (α-SMA) mRNA in BD, AMLN, and SGLT2I mice (n = 5–8). (D) α-SMA-stained paraffin-embedded sections of liver tissue from BD, AMLN, and SGLT2I mice. Areas of α-SMA staining in the livers of BD, AMLN, and SGLT2I mice (n = 5–8). Magnification, 200×. Scale bars: 200 μm. Results are the mean ± SD. Significance was determined using the Student’s t-test (*p<0.05).