Table 1. Characteristics of model mice.
| Parameters | BD | AMLN | SGLT2I |
|---|---|---|---|
| Food intake (g/day) | 3.41±0.13 | 3.46±0.13 | 3.58±0.21 |
| Body weight (g) | 28.9±1.4 | 39.7±2.8* | 39.6±1.1* |
| Liver weight (g) | 1.26±0.10 | 3.32±0.37* | 2.77±0.42*† |
| Weight of epididymal adipose tissue (g) | 0.23±0.08 | 1.09±0.18* | 1.10±0.10* |
| Fasting plasma glucose (mg/dL) | 90.7±32.2 | 203.5±55.2* | 142.4±41.6*† |
| Insulin (ng/mL) | 0.32±0.26 | 1.13±0.56* | 0.48±0.26† |
| HOMA-IR | 1.96±2.0 | 15.5±9.7* | 4.8±3.3† |
| Total cholesterol (mg/dL) | 97.7±5.4 | 270.1±47.1* | 200.2±23.8*† |
| AST (IU/L) | 40.5±8.1 | 400.4±136.1* | 194.0±114.6*† |
| ALT (IU/L) | 26.5±15.0 | 471.9±149.0* | 178.8±122.2*† |
| Free fatty acid (uEQ/L) | 938±293.1 | 1325.4±140.8* | 1154.2±106.9† |
HOMA-IR, the homeostasis model assessment of insulin resistance; AST, aspartate aminotransferase; ALT, alanine aminotransferase. Data are the mean ± SD (n = 5–8). Significance was determined using the Student’s t-test:
* p<0.05 versus BD mice
† p<0.05 versus AMLN mice