Table 2. Liver pathology scores.
Parameter | BD | AMLN | SGLT2I |
---|---|---|---|
Steatosis | 0 | 3.0* | 2.4±0.6*† |
Lobular Inflammation | 0 | 1.8±0.8* | 0.8±0.8*† |
Hepatocyte Ballooning | 0 | 0.2±0.4 | 0 |
NAS | 0 | 5.0±0.7* | 3.2±0.8*† |
Fibrosis stage | 0 | 1.6±0.5* | 0.8±0.4*† |
NAFLD activity score (NAS) and fibrosis stage were scored according to the method described by Kleiner et al. [27], as outlined in S1 Table. NAS, NAFLD Activity Score. Data are the mean ± SD (n = 5 each). Significance was determined using the Student’s t-test:
* p<0.05 versus BD mice
† p<0.05 versus AMLN mice