Table 2. Participants’ characteristics.
Author [year] | N | Sex (F/M) | Age [SD] (years) | Age range (years) | Gene mutation | Onset of symptoms (age) | Study group |
---|---|---|---|---|---|---|---|
Patterson [1993] | 5 | − | − | − | − | − | Intervention |
5 | − | − | − | − | − | Intervention | |
5 | − | − | − | − | − | Intervention | |
5 | − | − | − | − | − | Intervention | |
5 | − | − | − | − | − | Intervention | |
Patterson [2007] | 20 | 11/9 | 25 [9] | 12-42 | − | Juvenile/adulthood | Intervention |
9 | 4/5 | 22 [7] | 13-32 | − | Juvenile/adulthood | Control | |
12 | 7/5 | 7 [2] | 4-11 | − | Neonatal/early childhood, late childhood | Intervention | |
Patterson [2010] | 12 | 7/5* | 7 [2]* | 4-11* | − | Neonatal/early childhood, late childhood | Intervention |
10 | 7/5* | 7 [2]* | 4-11* | − | Neonatal/early childhood, late childhood | Follow-up | |
10 | 7/5* | 7 [2]* | 4-11* | − | Neonatal/early childhood, late childhood | Follow-up | |
Pineda [2010] | 5 | 3/2 | − | <6 | NPC1 | Neonatal/early childhood | Intervention |
4 | 2/2 | − | 6-11 | NPC1 | Late childhood | Intervention | |
7 | 2/5 | − | >12 | NPC1 | Juvenile/adulthood | Intervention | |
1 | 1/0 | 8 | − | Asymptomatic | Control | ||
Wraith [2010] | 20 | 15/14* | 24 [9]* | 12-42* | − | Juvenile/adulthood | Intervention |
9 | 15/14* | 24 [9]* | 12-42* | − | Juvenile/adulthood | Control | |
17 | 15/14* | 24 [9]* | 12-42* | − | Juvenile/adulthood | Follow-up | |
8 | 15/14* | 24 [9]* | 12-42* | − | Juvenile/adulthood | Follow-up | |
16 | 15/14* | 25 [9]* | 12-42* | − | Juvenile/adulthood | Follow-up | |
Héron [2012] | 1 | 1/0 | 2 months | 12-18* | NPC2 | Neonatal/early childhood | Intervention |
8 | 5/3 | <6 | 12-18* | NPC1 | Neonatal/early childhood | Intervention | |
8 | 3/5 | 6-11 | 12-18* | NPC1 | Late childhood | Intervention | |
3 | 2/1 | >12 | 12-18* | NPC1 | Juvenile/adulthood | Intervention | |
Fecarotta [2015] | 2 | 0/2 | 1 [1] | <1 to 2 | NPC1/NPC2 | Early infantile | Intervention |
6 | 5/1 | 6 [4] | 3-15 | NPC1 | Late infantile | Intervention | |
9 | 6/3 | 11 [2] | 10-19 | NPC1 | Juvenile | Intervention | |
6 | 4/2 | 28 [8] | 18-43 | NPC1/NPC2 | Adult | Intervention |
*, values for the total sample; −, not available data.