Figure 6. Development of age-related renal inflammation, fibrosis, and dysfunction in tg^sm/p22phox mice.

(A and B) Consecutive 6-micron sections were obtained from paraffin-embedded mouse kidneys and were stained with anti-CD3 and Masson’s trichrome blue. Images are ×20 magnification. Scale bars: 100 μm. (C and D) Mice received a single i.p. injection of normal saline equal to 10% of body weight, and urine/sodium excretion in the subsequent 4 hours were monitored. These data were analyzed with 2-way ANOVA (n = 6–8).