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. 2015 Nov 23;126(1):112–122. doi: 10.1172/JCI84669

Figure 6. Inhibition of NCX attenuates atrial and ventricular arrhythmogenesis in F1759A-dTG mice.

Figure 6

(A) Schematic depicting proposed mechanisms of arrhythmogenesis in F1759A-dTG mice. (B) Diary plot of fraction of AF/hour during a 20-hour period for 5 male F1759A-dTG mice. Burden of AF was determined by manually reviewing the entire 20-hour period. (C) Diary plot of fraction of AF/hour for same 5 male F1759A-dTG mice during a 20-hour period after i.p. injection of SEA-0400. (D) Graph (left) summarizing fraction of AF during 20-hour period before (white bars) and after (blue bars) single i.p. injection of SEA-0400 for each mouse. Percent change is shown above each data pair. Graph (right) showing fraction AF/hour before and after SEA injection for the 5 F1759A-dTG mice. Data are presented as mean ± SEM. *P < 0.05; t test. (E) Quantification of number of PVC normalized to pre-SEA. Data are presented as mean ± SEM. *P < 0.05; t test. (F) Bar graph showing QT interval before and after SEA-0400.