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. 2015 Dec 14;126(1):335–348. doi: 10.1172/JCI81480

Figure 3. CDK4 promotes insulin sensitivity in vivo.

Figure 3

(A–C) Fasting glycemia of 17- to 21-week-old Cdk4+/+ and Cdk4nc (n = 8) mice (A), 15- to 17-week-old Cdk4flox/flox mice infected with AAV8-mini/aP2-null (n = 5) or AAV8-mini/aP2-cre virus (n = 4) (B), and 33- to 36-week-old Cdk4+/+ and Cdk4R24C/R24C mice (n = 12) (C). (D–F) Fed serum insulin of 21-week-old Cdk4+/+ and Cdk4nc mice (n = 7) (D), 15- to 17-week-old Cdk4flox/flox mice infected with AAV8-mini/aP2-null (n = 5) or AAV8-mini/aP2-cre virus (n = 4) (E), and 29- to 33-week-old Cdk4+/+ and Cdk4R24C/R24C mice (n = 8) (F). (G–I) GTT of 20- to 23-week-old Cdk4+/+ and Cdk4nc mice (n = 7) (G), 15-to 17-week-old Cdk4flox/flox mice infected with AAV8-mini/aP2-null (n = 5) or AAV8-mini/aP2-cre (n = 4) (H), and 36-week-old Cdk4+/+ and Cdk4R24C/R24C mice (n = 6) (I). (J–L) ITT of 24-week-old Cdk4+/+ and Cdk4nc mice (n = 5) (J), 14- to 16-week-old Cdk4flox/flox mice infected with AAV8-mini/aP2-null (n = 5) or AAV8-mini/aP2-cre virus (n = 4) (K), and 30-week-old Cdk4+/+ and Cdk4R24C/R24C mice (n = 5–11) (L). AUC for GTT and ITT was analyzed and is shown below the curves. Data were expressed as mean ± SEM. Statistically significant differences were determined with unpaired 2-tailed Student’s t tests. *P < 0.05.