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. 2015 Dec 7;126(1):254–265. doi: 10.1172/JCI79775

Figure 7. DMPC liposome and glucosylceramide synthase inhibitor D-PDMP synergistically induce apoptosis in vitro.

Figure 7

(A) Cell viability of LNM35 and TIG112 cells treated with 0, 5, 10, or 20 μM D-PDMP, with or without 40 μM DMPC liposome (mean ± SD; n = 4). (B) Isobologram analysis of DMPC liposome and D-PDMP. Horizontal and vertical axes indicate the proportions of D-PDMP and DMPC liposome, respectively. For additional analyses, see Supplemental Figure 11. (C) Effects of siCERS6-1 on apoptosis induced by 10 μM D-PDMP and/or 40 μM DMPC liposome (mean ± SD; n = 4). (D) Ceramide quantification in LNM35 cells treated with 200 μM DMPC liposome and/or 20 μM D-PDMP (mean ± SD; n = 3).