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. 2015 Nov 30;13(1):8–24. doi: 10.1021/acs.molpharmaceut.5b00626

Figure 5.

Figure 5

Targeting iron oxide (IO) nanoparticles with a single-chain EGFR (ScFvEGFR) antibody for MRI. (A) Nanoparticles were constructed by coating IO nanoparticles with an amphiphilic copolymer containing short polyethylene glycol chains. Second, nanoparticles were functionalized with ScFvEGFR in the presence of ethyl-3-dimethyl aminopropyl carbodiimide (EDAC). (B) MR images displayed enhanced pancreatic tumor contrasts (yellow arrow) in mice 5 and 30 h postinjected with ScFvEGFR-IO nanoparticles. Also, ex vivo confirmation of cancerous lesions within the pancreas is shown (blue arrow). (C) For comparison, minimal contrasts differences are seen postinjection of nontargeted IO nanoparticles. Reprinted with permission from ref (120). Copyright 2009 Wiley.