Table 2.
Fractional anisotropy (FA) in white matter parcellated regions of interest (ROIs) using the Desikan‐Killiany atlas in FreeSurfer
| ROI | R/L | HC (N = 39) | MDD (N = 139) | F‐test |
|---|---|---|---|---|
| Caudal ACC | R | .62 ± .04 | .62 ± .05 | F(1,173) = 0.20, P =.66 |
| L | .61 ± .04 | .61 ± .05 | F(1,173) = 0.02, P =.88 | |
| Rostral ACC | R | .58 ± .05 | .59 ± .05 | F(1,173) = 0.21, P =.65 |
| L | .55 ± .04 | .54 ±. 04 | F(1,173) = 0.50, P =.48 | |
| Medial orbital frontal | R | .43 ± .03 | .43 ± .03 | F(1,173) = 0.79, P =.38 |
| L | .41 ± .04 | .40 ± .03 | F(1,173) = 1.52, P =.22 | |
| Dorsomedial prefrontal | R | .48 ± .03 | .49 ± .03 | F(1,173) = 0.67, P = .41 |
| L | .49 ± .03 | .49 ± .03 | F(1,173) = 0.39, P = .54 |
F‐test includes age, site and sex as covariates. Data are presented as mean ± standard deviation.
ACC, anterior cingulate cortex; HC, healthy control; L, left; MDD, major depressive disorder; R, right.