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. Author manuscript; available in PMC: 2017 Jan 21.
Published in final edited form as: Org Biomol Chem. 2015 Dec 3;14(3):1049–1064. doi: 10.1039/c5ob02241j

Scheme 5.

Scheme 5

Synthesis of 131,173-diaspartyl chlorin e6 methyl ester (13). (Reagents: i. DCC, DMAP, CH2Cl2, 1 h; ii. 0.5 M NaOMe/MeOH, 0 °C, 99% (2 steps); iii. HOBt, TBTU, DMF, L-Asp di-t-Bu.HCl, DIEA, CH2Cl2, rt, 48 h, 48%; iv. TFA/CH2Cl2, thioanisole, 6 h, rt, 53%.).