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. Author manuscript; available in PMC: 2016 Jan 5.
Published in final edited form as: Analyst. 2016 Jan 4;141(2):403–415. doi: 10.1039/c5an01995h

Fig. 3. Aptamer probes for IHC staining of FFPE tumor tissues.

Fig. 3

(a) Tissue sections of CD30-positive anaplastic large cell lymphoma (ALCL) were immunostained with aptamer probes, or antibodies as standard control. After antigen retrieval at 37 °C and probing for 20 min, tissue sections were probed with aptamers and lymphoma cells were specifically immunostained. In contrast, antibody immunostaining of lymphoma cells required higher antigen retrieval temperature (97 °C) for a long probing time (90 min); (b) Aptamer probes showed non-specific staining (brown color) in the tumor necrotic area compared to the antibody stain (depicted with red arrows and circles).