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. 2016 Jan 5;11(1):e0146504. doi: 10.1371/journal.pone.0146504

Fig 4. Imaging of IGF-1R targeting of liver metastasis.

Fig 4

Anti-IGF-1R conjugated to PEGylated 650 nm dye selectively labeled the HCT 116-GFP metastatic tumors. Both in vivo (A) and ex vivo (B) imaging show that the 650 nm fluorophore-conjugated IGF-1R antibodies co-localized with HCT 116-GFP fluorescence and more accurately demarked the tumor compared to bright light imaging (white arrowheads). H & E staining of tissue sample (x200) expressing fluorescence confirms the presence of metastatic tumor in the mouse liver.