Fig. 1. CaMKII oxidization and sinus node dysfunction in Ang II-infused mice. (A) Representative ECG recordings from Langendorff-perfused hearts isolated from mice infused with Ang II or saline for 3 weeks. (B) Ang II-infused mice have more sinus pauses than saline-infused mice. (C) Western blots shows ox-CaMKII and T-CaMKII from right atrial tissue obtained from infused with Ang II or saline for 3 weeks. Ang II, angiotensin II; CaMKII, calmodulin kinase II; ECG, electrocardiography; ox-CaMKII, oxidized-CaMKII; T-CaMKII, total CaMKII. Data are shown as the means±SEM of 3-6 mice per group. ^a)Significantly different (P<0.05) from saline infused control.