Fig. 5. Kaempferol improves the recovery of Ang II-induced sinus nodal dysfunction. (A) ECG recordings from Langendorff-perfused hearts isolated from mice infused with Ang II in the absence or presence of a kaempferol for 3 weeks. (B) Together with kaempferol, Ang II infused mice decreased sinus pauses than Ang II-infused alone. (C) Western blots demonstrates ox-CaMKII and T-CaMKII from right atrial tissue obtained from infused with Ang II, Ang II+kaempferol, or saline for 3 weeks. Ang II, angiotensin II; CaMKII, calmodulin kinase II; ECG, electrocardiography; ox-CaMKII, oxidized-CaMKII; T-CaMKII, total CaMKII. Data are shown as the means±SEM of 3-6 mice per group. ^a)Significantly different (P<0.05) from Saline treated control. ^b)Significantly different (P<0.05) from Ang II treated control.