Fig. 3. Comparison of bone mineral density between normal and HAC dogs at trabecular and cortical bone. Box-and-whisker plots show significantly lower tBMDs of HAC patients than those of normal dogs (A). Significant differences were only observed in T13, L1, L2 L4, L5, and L6. The central boxes represent values from the lower to upper quartile (25th to 75th percentile). The middle line represents the median. Significant differences were determined by a t-test. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.