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. 2015 Nov 9;68:29–41. doi: 10.1007/s00251-015-0880-z

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© The Author(s) 2015

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — HLA-E-leader peptide complexes confer protection against NK cell mediated lysis. Cytotoxicity assay showing the percentage of lysed target cells. Depicted is the average of three independent experiments, shown FACS plots are exemplary. T2E*01:01 and T2E*01:03 cells were lysed in the absence of peptide. Top panel: T2E*01:01^VMAPRTLVL showed decreased cytotoxicity (7.4 %) compared to T2E*01:01^VMAPRTLFL (9.0 %), T2E*01:01^VMAPRTLIL (8.3 %), or T2E*01:01^VMAPRALLL (13.9 %). Bottom panel: T2E*01:03^VMAPRTLFL showed decreased cytotoxicity (7.4 %) compared to T2E*01:03^VMAPRTLVL (9.0 %), T2E*01:03^VMAPRTLIL (8.3 %), or T2E*01:03^VMAPRALLL (13.9 %). Overall cytotoxicity was decreased in T2E*01:03 in comparison to T2E*01:01