FIG 1 .
hdc+ L. reuteri attenuates colonic inflammation in vivo. (A) Time line of the mouse experiments. After 10 days of acclimatization, 8-week-old female BALB/c mice received 5 × 109 CFU of bacteria in MRS or MRS medium only by orogastric gavage daily for 7 days. Acute colitis was induced by intrarectal instillation of TNBS-ethanol before the sixth gavage, and colitis severity was evaluated in 2 days. (B to D) Weight loss (B), Wallace scores (C), and SAA concentrations (D) of mice challenged with or without TNBS and gavaged with or without L. reuteri 6475. (E and F) Representative microscopic colonic images (hematoxylin and eosin stained) (E) and Ameho scores (F) from mice in the healthy control group (MRS/PBS), the colitis control group (MRS/TNBS), and the L. reuteri-treated group (L. reuteri 6475/TNBS).