FIG 4 .

Inactivation of the L. reuteri histidine decarboxylase gene diminishes its ability to suppress intestinal inflammation. The anti-inflammatory effects of hdcA within an isogenic mutant which does not produce histamine were compared with those of wild-type L. reuteri 6475 using the TNBS colitis model. The wild-type strain attenuated colitis compared with the medium-control group (MRS/TNBS), whereas the hdcA mutant yielded diminished effects in terms of weight loss (A), Wallace scores (B), and SAA concentrations (C).