FIG 5 .

l-histidine deficiency diminishes anti-inflammatory effects. The anti-inflammatory effects of L. reuteri 6475 were compared in mice fed with different diets using the TNBS colitis model. Mice fed a regular diet or an amino acid defined diet showed decreased Wallace scores (A) and plasma SAA concentrations (B) when receiving L. reuteri 6475 compared to the MRS medium control. When mice were fed an l-histidine-deficient diet, L. reuteri 6475 showed diminished anti-inflammatory effects in terms of Wallace scores and SAA concentrations.