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. 2015 Dec 15;6(6):e01358-15. doi: 10.1128/mBio.01358-15

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Copyright © 2015 Gao et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original author and source are credited.

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FIG 6 — Activation of H2R is required for the anti-inflammatory effects. (A) Immunohistochemistry studies using H2R-specific antibody showed that H2R was expressed in 9-week-old BALB/c mice, with high intensity in the villi and crypts (red arrows). (B to D) Mice that received pyrilamine (Pyr) did not show an effect on the anti-inflammatory effects of L. reuteri 6475, while mice that received ranitidine (Ran) showed a diminished ability for L. reuteri 6475 to attenuate colitis, as indicated by weight loss (B), Wallace scores (C), and plasma SAA concentrations (D).