FIG 1 .

Metastatic tumors contain integrations within clonally expanded cells. Each pie represents a specific tissue that underwent high-throughput integration site sequencing. Each slice represents a unique integration, and the size of each slice corresponds to the number of sonication breakpoints observed for that integration. The integrations that exhibit the greatest clonal expansion (i.e., the most breakpoints) are shown. A total of 200 breakpoints are shown for each sample. (Left) C3-B256 metastatic liver tumor exhibits extensive clonal expansion. (Middle) D1-G157 bursa with neoplastic follicles contains some integrations in moderately expanded clones. (Right) D4-G163 non-tumor liver exhibits very few integrations in expanded clones.