Abstract
Wagenvoort, C. A., Dingemans, K. P., and Lotgering, G. G. (1974).Thorax, 29, 511-521. Electron microscopy of pulmonary vasculature after application of fulvine. This is an electron microscopic study of the effect of fulvine on the pulmonary arteries and veins of the rat. Marked constriction of the arteries was evident from excessive crenation of the internal elastic membrane, resulting in squeezing of nuclei of both smooth muscle cells and endothelial cells between the folds on either side of this lamina.
Four weeks after fulvine administration fibrin deposits were found in the arterial media followed by necrosis of muscle cells. In the adventitia there was a new development of smooth muscle fibres, probably derived from fibroblasts.
In pulmonary veins and venules there was also constriction and hyperplasia of smooth muscle. The muscle cells showed pronounced cytoplasmic excrescences protruding into the endothelial layer. This probably reflects constriction of the muscle cells. As in the arteries, fibrin deposits and necrosis of muscle cells were observed from the fourth week onward.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fay F. S., Delise C. M. Contraction of isolated smooth-muscle cells--structural changes. Proc Natl Acad Sci U S A. 1973 Mar;70(3):641–645. doi: 10.1073/pnas.70.3.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kay J. M., Heath D., Smith P., Bras G., Summerell J. Fulvine and the pulmonary circulation. Thorax. 1971 May;26(3):249–261. doi: 10.1136/thx.26.3.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kay J. M., Smith P., Heath D. Electron microscopy of Crotalaria pulmonary hypertension. Thorax. 1969 Sep;24(5):511–526. doi: 10.1136/thx.24.5.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Merkow L., Kleinerman J. An electron microscopic study of pulmonary vasculitis induced by monocrotaline. Lab Invest. 1966 Mar;15(3):547–564. [PubMed] [Google Scholar]
- Nagle R. B., Kneiser M. R., Bulger R. E., Benditt E. P. Induction of smooth muscle characteristics in renal interstitial fibroblasts during obstructive nephropathy. Lab Invest. 1973 Oct;29(4):422–427. [PubMed] [Google Scholar]
- Wagenvoort C. A. Hypertensive pulmonary vascular disease complicating congenital heart disease. A review. Cardiovasc Clin. 1973;5(1):43–60. [PubMed] [Google Scholar]
- Wagenvoort C. A., Wagenvoort N., Dijk H. J. Effect of fulvine on pulmonary arteries and veins of the rat. Thorax. 1974 Sep;29(5):522–529. doi: 10.1136/thx.29.5.522. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wissler R. W. The arterial medial cell, smooth muscle, or multifunctional mesenchyme? Circulation. 1967 Jul;36(1):1–4. doi: 10.1161/01.cir.36.1.1. [DOI] [PubMed] [Google Scholar]