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. 2016 Jan 6;36(1):153–161. doi: 10.1523/JNEUROSCI.3114-15.2016

Figure 7.

Figure 7.

Effect on JSI of mPFC microinjections of muscimol (0.5 μl bilaterally, 500 ng or saline vehicle) immediately followed by intraperitoneal injections of ketamine, 2 h before IS. JSI was measured 24 h after IS. In A, the groups include the following: PL saline and intraperitoneal saline in HC (V/V–HC), PL saline and intraperitoneal ketamine in HC (V/K–HC), PL muscimol and intraperitoneal ketamine in HC (M/K–HC), PL saline and intraperitoneal saline before IS (V/V–IS), PL saline and intraperitoneal ketamine before IS (V/K–IS), PL muscimol and intraperitoneal ketamine before IS (M/K–IS), and PL muscimol and intraperitoneal saline before IS (M/V–IS). For a site specificity control, muscimol was microinjected 2 mm caudal to the PL (into Cg2 cortex, site control), or into the IL cortex (B) at the same AP level as PL, followed by the same treatments as above. n = 7 for the site control group, n = 8 for all other groups.