Figure 3.

Inhibition of P2Y1 during BAO prevents the injury-induced alterations in chemosensitive muscle afferent prevalence. A, A decrease in the percentage of cells responsive to low metabolite concentrations is observed after ischemic injury (BAO or PenCON+BAO) compared with Naive mice, but this is not observed in the selective P2Y1-knockdown group. B, There are no significant alterations in the numbers of group III/IV muscle afferents that respond to high concentrations of metabolites in any condition. C, The observed increase in afferents that respond to both high and low concentrations of metabolites in the BAO and PenCON+BAO groups is also prevented by selective knockdown of P2Y1. χ-Squared analysis, *p < 0.05, **p < 0.01, ***p < 0.001 versus Naive and PenY1+BAO.