Figure 4.

Knockdown of P2Y1 during BAO blocks the increased firing in response heat stimuli in muscle afferents. A, Increased mean peak instantaneous frequencies in response to heat stimulation of the muscles is observed in mice with BAO and mice with PenCON+BAO compared with Naives, but this is not observed in the PenY1+BAO group. B, Examples of responses to heat stimulation of the muscles during ex vivo recording in Naive, BAO, and PenY1+BAO mice. Kruskall–Wallis one-way ANOVA on ranks with Dunn's post hoc test, *p < 0.05 vs Naive and PenY1.