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. 2016 Jan 6;36(1):204–221. doi: 10.1523/JNEUROSCI.1751-15.2016

Figure 1.

Figure 1.

Latent sensitization in MOR KO mice and effect of receptor antagonists. MOR KO mice (MOR KO CFA, n = 8) or their WT littermates were injected with 5 μl CFA (WT CFA, n = 9) or 5 μl of saline (WT saline, n = 3) in the hindpaw. A, Responses to von Frey hairs were tested on the days indicated. Short-term responses to drugs are not shown. Holm-Sidak's post hoc tests: *p < 0.05, ***p < 0.001 compared with WT saline; †p < 0.05, ††p < 0.01, †††p < 0.001 compared with WT CFA. B, On day 34, the MOR inverse agonist NTX (3 mg/kg) was injected subcutaneously and von Frey responses tested every 20 min and at 24 h. C, On day 41, the MOR neutral antagonist 6β-naltrexol (10 mg/kg) was injected subcutaneously. D, On day 48, the α2AR antagonist BRL44408 (1 mg/kg) was injected subcutaneously. E, On day 55, the DOR antagonist naltrindole (3 mg/kg) was injected subcutaneously. F, New groups of WT mice were injected with 5 μl CFA (n = 14) or saline (n = 6) in the hindpaw and on day 29 with naltrindole (3 mg/kg, s.c.). Holm-Sidak's post hoc tests (for B–F): *p < 0.05, **p < 0.01, ***p < 0.001 compared with 0 min.