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. 2016 Jan 6;36(1):204–221. doi: 10.1523/JNEUROSCI.1751-15.2016

Figure 5.

Figure 5.

Effect of the KOR antagonists nor-BNI and JDTic in rats and mice with CFA-induced latent sensitization. A, PWTs of rats (n = 5) injected in the hindpaw with 50 μl of CFA subcutaneously. B, On day 30, these rats received 1.3 nmol nor-BNI (a KOR antagonist) intrathecally, which reinstated hyperalgesia 12 h after the injection. C, PWTs of rats (n = 8) with intrathecal catheters that were injected in the hindpaw with 50 μl of saline subcutaneously. D, On day 32, the saline-injected rats (n = 8) received intrathecal nor-BNI (1.3 nmol). E, Mice received 5 μl of CFA (n = 6) or 5 μl of saline (n = 6) subcutaneously in the hindpaw. F, On day 43, the mice received an injection of the KOR antagonist JDTic (10 mg/kg, s.c.), which reinstated hyperalgesia after 12 h. Holm-Sidak's post hoc tests of two-way ANOVA: **p < 0.01, ***p < 0.001 compared with baseline (0 d or 0 min).