Table 2.

Two-way ANOVA of the data shown in Figure 2 (NTX and 6β-naltrexol)

Row	Figure	Experiment	n	Variable 1	Variable 2	Interaction	Subject matching
1	2A	CFA	6	Time (CFA)	Side	p < 0.0001	p = 0.001
				p < 0.0001	p = 0.0096	F(9,90) = 7.8	F(10,90) = 7.88
				F(9,90) = 8.98	F(1,10) = 10.21
2	2B	CFA (NTX)	6	Time (NTX)	Side	p = 0.15	p < 0.0001
				p < 0.0001	p = 0.25	F(6,60) = 1.6	F(10,60) = 6.45
				F(6,60) = 40	F(1,10) = 1.5
3	2C	CFA (6β-naltrexol)	6	Time (6β-naltrexol)	Side	p = 0.89	p < 0.0001
				p = 0063	p = 0.24	F(6,60) = 0.38	F(10,60) = 5.68
				F(9,90) = 3.37	F(1,10) = 1.5
4	2D	CFA (NTX + 6β-naltrexol)	6	Time (NTX + 6β-naltrexol)	Side	p = 0.999	p < 0.0001
				p = 0.42	p = 0.81	F(6,60) = 0.04	F(10,60) = 14.6
				F(9,90) = 1.02	F(1,10) = 0.06
5	2E	Saline	8	Time (saline)	Side	p = 0.50	p < 0.0001
				p = 0.066	p = 0.97	F(7,98) = 0.91	F(14,98) = 10.3
				F(7,98) = 1.97	F(1,14) = 0.002
6	2F	Saline (NTX)	8	Time (NTX)	Side	p = 0.95	p < 0.0001
				p = 0.87	p = 0.29	F(6,84) = 0.28	F(14,84) = 7.08
				F(6,84) = 0.42	F(1,14) = 1.2

Each panel in Figure 2 (indicated in the second column) was analyzed independently by two-way ANOVA. In the fourth column, n is the number of animals in the experiment. In the fifth and sixth columns, the variable is identified first: “time” refers to the time after the injection of the compound in parentheses; “side” is ipsilateral versus contralateral paw. Subscript numbers in the F ratio are the degrees of freedom and the residual.