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. 2016 Jan 6;36(1):204–221. doi: 10.1523/JNEUROSCI.1751-15.2016

Table 3.

Two-way ANOVA of the data shown in Figure 3 (BRL44408) and Figure 4 (naltrindole)

Row Figure Experiment n Variable 1 Variable 2 Interaction Subject matching
1 3A CFA 9 Time (CFA) Side p < 0.0001 p < 0.0001
p < 0.0001 p < 0.0001 F(7,112) = 18.10 F(16,112) = 7.30
F(7,112) = 18.66 F(1,16) = 30.49
2 3B CFA, BRL44408 0.3 nmol 6 Time (BRL44408) Side p = 0.75 p < 0.0001
p = 0.0064 p = 0.93 F(5,50) = 0.53 F(10,50) = 6.25
F(5,50) = 3.69 F(1,10) = 0.007
3 3C CFA, BRL44408 3 nmol 9 Time (BRL44408) Side p = 0.17 p < 0.0001
p < 0.0001 p = 0.25 F(5,80) = 1.60 F(16,80) = 3.88
F(5,80) = 19.34 F(1,16) = 1.43
4 3D saline 8 Time (saline) Side p = 0.92 p < 0.0001
p = 0.018 p = 0.78 F(7,98) = 0.36 F(14,98) = 13.1
F(7,98) = 2.56 F(1,14) = 0.08
5 3E saline (BRL 44408) 8 Time (BRL44408) Side p = 0.73 p < 0.0001
p = 0.033 p = 0.72 F(6,84) = 0.60 F(14,84) = 12.1
F(6,84) = 2.42 F(1,14) = 0.14
6 4A CFA 11 Time (CFA) Side p < 0.0001 p < 0.0001
p < 0.0001 p = 0.0001 F(7,140) = 21.1 F(20,140) = 12.8
F(7,140) = 23.15 F(1,20) = 22.94
7 4B CFA, naltrindole i.th. 11 Time (naltrindole) Side p = 0.87 p = 0.0007
p = 0.0088 p = 0.22 F(5,100 = 0.36 F(20,100 = 2.66
F(5,100) = 3.28 F(1,20) = 1.60
8 4C CFA, naltrindole s.c. 8 Time (naltrindole) Side p = 0.14 p < 0.0001
p = 0.0033 p = 0.97 F(5,70) = 1.72 F(14,70) = 8.34
F(5,70) = 3.93 F(1,14) = 0.0017
9 4D saline 8 Time (saline) Side p = 0.30 p < 0.0001
p = 0.0001 p = 0.71 F(7,98) = 1.22 F(14,98) = 7.66
F(7,98) = 4.7 F(1,14) = 0.15
10 4E saline, naltrindole s.c. 8 Time (naltrindole) Side p = 0.75 p = 0.006
p = 0.49 p = 0.022 F(5,70) = 0.53 F(14,70) = 2.51
F(5,70) = 0.89 F(1,14) = 6.6

Each panel in Figure 3 or 4 (indicated in the second column) was analyzed independently by two-way ANOVA. In the fourth column, n is the number of animals in the experiment. In the fifth and sixth columns, the variable is identified first: “time” refers to the time after the injection of the compound in parentheses; “side” is ipsilateral versus contralateral paw. Subscript numbers in the F ratio are the degrees of freedom and the residual.