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. 2016 Jan 6;8:82. doi: 10.3389/fnmol.2015.00082

FIGURE 2.

FIGURE 2

Pathological changes in the gastrocnemius muscle of symptomatic ALS mice. Haematoxylin and eosin-stained cross-sections of the gastrocnemius muscle from 4-month-old wild-type (A) and SOD1 transgenic (B) mice show similar regular size of muscle fibers and normal architecture of the muscle; bar = 50 μm. Sections from aged-matched symptomatic SOD1G93A mice show pathological changes in muscle structure characteristic for ALS (C–F). Larger regions of the muscle sections at lower magnification (bar = 100 μm) show characteristic grouped atrophy in the muscle of SOD1G93A mice (C). Muscle tissue from symptomatic SOD1G93A mice shows the presence of mixed fiber types of different size. Group of small and atrophic muscle fibers and presence of hypertrophied fibers in the gastrocnemius muscle from 4-month-old symptomatic mouse (D); bar = 50 μm. Group of the small and angular fibers at a higher magnification (bar = 20 μm) (E). Pyknotic nuclear clumb (arrow) present in the muscle of symptomatic SOD1G93A mice (F); bar = 20 μm.