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. 2015 Dec 8;113(12):1704–1711. doi: 10.1038/bjc.2015.397

Figure 3.

Figure 3

Kaplan–Meier curves for progression-free survival (PFS) (A) and overall survival (OS) (B) differentiated by the patients' mutational status are shown. Because of the excellent survival rate of pulmonary carcinoids, only high-grade cases are depicted. Of note, samples had mutations in both ATM and APC, showing an association to PFS (P=0.020). The relation of this double mutation has to be clarified. The PIK3CA mutated patients with high-grade tumours showed a reduced OS compared with their wild-type counterparts (P=0.040).