Fig. 1.

Regulation of DME mRNA levels in TRIF^+/+ and TRIF^−/− mice after LPS administration. TRIF^+/+ and TRIF^−/− were injected i.p. with saline or LPS (2 mg/kg), and livers were harvested at 16 hours (n = 5 or 6/group). RNA was isolated from the livers, and mRNA levels of Cyp3a11 and Ugt1a1 were determined by real-time PCR analysis as described earlier. All data are presented as ±S.D. and standardized for cyclophilin mRNA levels. Expression in saline-treated TRIF^+/+ mice was set to 1, and the -fold change after LPS-treatment was compared with that of the saline-treated controls. *Significant difference (P < 0.05) between saline and LPS groups. The experiments were repeated three times.