Fig. 3.

Regulation of DMET mRNA levels in C57BL/6 mice by poly I:C. C57BL/6 mice were injected i.p. with saline or polyI:C (5 mg/kg), and livers were harvested at 8 hours (A) and at 16 hours (B) (n = 5 or 6/group). RNA was isolated from the livers and mRNA levels of phase 1 and phase 2, and transporter genes were determined by real-time PCR analysis as described earlier. All data are presented as ±S.D. and standardized for cyclophilin mRNA levels. Expression in saline-treated mice was set to 1, and the -fold change after polyI:C-treatment was compared with that of the saline-treated controls. *Significant difference (P < 0.05) between saline and poly I:C groups. The experiments were repeated three times.