TABLE 3.
Unadjusted Associations of Allergic Disease Predictors with Elevated Internalizing Symptoms, Anxiety, and Depression BASC-2 T Scores at Age 7 Years
| Predictor Variables | Elevated Internalizing Symptoms T Scorea (n = 73) | Elevated Anxiety T Scoreb (n = 83) | Elevated Depression T Scorec (n = 59) | |||
|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Rhinitisd (n =203) | ||||||
| Allergic SPT+ (n = 119) | 2.6# | 1.6–4.4 | 1.7* | 1.0–2.8 | 2.4** | 1.4–4.2 |
| Persistent wheezingd (n = 52) | ||||||
| Allergic SPT+ (n = 29) | 3.2** | 1.4–7.3 | 1.8 | 0.8–4.5 | 2.8* | 1.2–7.0 |
| Dermatitisd (n = 71) | ||||||
| Atopic SPT+ (n = 45) | 1.2 | 0.5–2.8 | 1.4 | 0.7–3.1 | 0.6 | 0.2–1.9 |
| Sensitizatione (n = 312) | ||||||
| Food allergen SPT+ (n = 108) | 1.4 | 0.8–2.5 | 1.2 | 0.7–2.0 | 1.3 | 0.7–2.5 |
| Aeroallergen SPT+ (n = 274) | 1.2 | 0.8–2.0 | 1.1 | 0.7–1.7 | 1.1 | 0.7–1.9 |
| Multiple allergic diseasesf (SPT+; n = 147) | ||||||
| One allergic disease (n = 106) | 1.3 | 0.7–2.4 | 1.1 | 0.6–2.0 | 1.5 | 0.8–2.9 |
| Two or three allergic diseases (n = 41) | 3.7# | 1.8–7.6 | 2.2* | 1.1–4.7 | 2.4* | 1.0–5.5 |
| Allergic rhinitis plus allergic disease(s)g (SPT+; n = 119) | ||||||
| Allergic rhinitis alone (n = 83) | 1.7 | 0.9–3.3 | 1.4 | 0.7–2.5 | 2.0* | 1.0–3.9 |
| Allergic rhinitis plus 1 or 2 allergic diseases (n = 36) | 4.5# | 2.1–9.4 | 2.4* | 1.1–5.2 | 2.8** | 1.2–6.6 |
a
Internalizing composite scale BASC-2 T score >59.
b
Anxiety subscale BASC-2 T score >59.
c
Depression subscale BASC-2 T score >59.
d
Allergic rhinitis, allergic persistent wheezing, and atopic dermatitis as defined in Methods.
e
Seventy children with aeroallergen and food SPT positive results; thus, total does not equal the sum of the 2.
f
More than 1 of the following: SPT+ allergic rhinitis, SPT+ allergic persistent wheezing, and SPT+ atopic dermatitis at age 4 years.
g
Allergic rhinitis plus allergic persistent wheezing and/or atopic dermatitis.
*
P < .05, **P < .01, #P < .001. SPT, skin prick test