TABLE 4.

Adjusted Associations of Allergic Disease Predictors and Elevated Anxiety, Depressive, and Internalizing Disorder BASC-2 Scores at Age 7 Years

Predictor Variables	Elevated Internalizing Symptoms T Scorea (n = 73)		Elevated Anxiety T Scoreb (n = 83)		Elevated Depression T Scorec (n = 59)
	OR	95% CI	OR	95% CI	OR	95% CI
Rhinitisd (n = 203)
Allergic SPT+ (n = 119)	3.2#	1.8–5.8	2.0*	1.2–3.6	3.2#	1.7–6.5
Persistent wheezingd (n = 52)
Allergic SPT+ (n = 29)	2.7*	1.2–6.3	—e	—e	2.3	0.9–5.8
Multiple allergic diseasesf (SPT+; n = 147)
One allergic disease (n = 106)	1.2	0.6–2.3	1.1	0.6–2.1	1.5	0.7–2.9
Two or three allergic diseases (n = 41)	3.6#	1.7–7.6	2.2*	1.0–4.7	2.3	0.97–5.6
Allergic rhinitis plus allergic disease(s)g (SPT+; n = 119)
Allergic rhinitis alone (n = 83)	1.6	0.8–3.1	1.4	0.7-2.6	1.9	0.96–3.9
Allergic rhinitis plus 1 or 2 allergic diseases (n = 36)	4.3#	2.0–9.2	2.2*	1.0–4.9	2.7*	1.1–6.6

Covariates include gender, parental asthma, maternal education, BMI, and sleep disturbance. *P < .05, ^#P < .001. SPT, skin prick test.

^aInternalizing composite scale BASC-2 T score >59.

^bAnxiety subscale BASC-2 T score >59.

^cDepression subscale BASC-2 T score >59.

^dAllergic rhinitis, allergic persistent wheezing, and atopic dermatitis as defined in Methods.

^eMultiple regression analyses not performed because association was not significant in unadjusted models.

^fMore than 1 of the following: SPT+ allergic rhinitis, SPT+ allergic persistent wheezing, and SPT+ atopic dermatitis at age 4 years.

^gAllergic rhinitis plus allergic persistent wheezing and/or atopic dermatitis.