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Absence of effects of the urothelium on A1 adenosine receptor modulation of detrusor contraction. When the urothelium-suburothelium was left intact, CPA (3 µM) reduced the EFS-evoked contractions to 67.9% ± 7.5% of the control (n = 7). When the urothelium-suburothelium was removed, CPA (3 µM) reduced the EFS-evoked contractions to 55.9% ± 9.1% of the control (n = 7). The difference in the degree of reduction in EFS-evoked contractions was not significant (P = 0.32).
